Contribution of common chronic conditions to midlife physical function decline: The Study of Women’s Health Across the Nation

Table 4 Change in Self-Reported Physical Function Concurrent with the Development of New Chronic Conditions

Model Parameters	Clinically-Meaningful Depressive Symptoms^a		Osteoarthritis		Hypertension		Diabetes
Model Parameters	IRR^b	95% CI	IRR	95% CI	IRR	95% CI	IRR	95% CI
Number of Baseline Conditions	0.936	0.923, 0.949	0.974	0.963, 0.985	0.950	0.939, 0.961	0.946	0.936, 0.956
Time in Years	0.996	0.995, 0.997	0.998	0.997, 0.998	0.997	0.996, 0.997	0.996	0.995, 0.996
New Condition	0.995	0.975, 1.015	0.986	0.970, 1.002	1.033	1.015, 1.050	1.022	0.996, 1.048
New Condition x Time	0.998	0.996, 1.000	0.998	0.997, 0.999	0.995	0.993, 0.996	0.995	0.992, 0.997
Model Parameters	Osteoporosis		Cancer		Heart Disease		Stroke
Model Parameters	IRR	95% CI	IRR	95% CI	IRR	95% CI	IRR	95% CI
Number of Baseline Conditions	0.950	0.940, 0.959	0.942	0.932, 0.951	0.955	0.945, 0.964	0.946	0.936, 0.955
Time in Years	0.994	0.994, 0.995	0.995	0.994, 0.995	0.995	0.994, 0.995	0.995	0.994, 0.995
New Condition	0.990	0.969, 1.012	1.090	1.053, 1.126	1.014	0.971, 1.056	0.881	0.813,0.950
New Condition x Time	1.001	0.999, 1.003	0.993	0.990, 0.996	0.991	0.984, 0.995	1.002	0.996, 1.008

Note: Sample sizes vary between models because only women without the condition at analytic baseline (follow-up visit 4) were included. Models were adjusted for covariates, including age, race/ethnicity, financial strain, marital status, education, menopausal status, hormone use, smoking, body mass index, health status, bodily pain, fracture history, and physical activity. ^aClinically relevant depressive symptoms, defined as Center for Epidemiologic Studies Depression Scale score of ≥16 points. ^bIRR: Incident rate ratio. To obtain percent differences in physical function associated with each model parameter, subtract the IRR from 1 and multiply by 100

ISSN: 2054-2690